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In vitro–in vivo correlations for drugs eliminated by glucuronidation: Investigations with the model substrate zidovudine
AIMS: To investigate the effects of incubation conditions on the kinetic constants for zidovudine (AZT) glucuronidation by human liver microsomes, and whether microsomal intrinsic clearance (CL(int)) derived for the various conditions predicted hepatic AZT clearance by glucuronidation (CL(H)) in viv...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Blackwell Science Inc
2002
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1874472/ https://ncbi.nlm.nih.gov/pubmed/12445028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01669.x |
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