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Scaling factors for the in vitro–in vivo extrapolation (IV–IVE) of renal drug and xenobiotic glucuronidation clearance
AIM: To determine the scaling factors required for inclusion of renal drug glucuronidation clearance in the prediction of total clearance via glucuronidation (CL(UGT)). METHODS: Microsomal protein per gram of kidney (MPPGK) was determined for human ‘mixed’ kidney (n = 5) microsomes (MKM). The glucur...
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| Publicat a: | Br J Clin Pharmacol |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley and Sons Inc.
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4876189/ https://ncbi.nlm.nih.gov/pubmed/26808419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12889 |
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