Scaling factors for the in vitro–in vivo extrapolation (IV–IVE) of renal drug and xenobiotic glucuronidation clearance

AIM: To determine the scaling factors required for inclusion of renal drug glucuronidation clearance in the prediction of total clearance via glucuronidation (CL(UGT)). METHODS: Microsomal protein per gram of kidney (MPPGK) was determined for human ‘mixed’ kidney (n = 5) microsomes (MKM). The glucur...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Knights, Kathleen M., Spencer, Shane M., Fallon, John K., Chau, Nuy, Smith, Philip C., Miners, John O.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Drug Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876189/
https://ncbi.nlm.nih.gov/pubmed/26808419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12889
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