טוען...
Scaling factors for the in vitro–in vivo extrapolation (IV–IVE) of renal drug and xenobiotic glucuronidation clearance
AIM: To determine the scaling factors required for inclusion of renal drug glucuronidation clearance in the prediction of total clearance via glucuronidation (CL(UGT)). METHODS: Microsomal protein per gram of kidney (MPPGK) was determined for human ‘mixed’ kidney (n = 5) microsomes (MKM). The glucur...
שמור ב:
| הוצא לאור ב: | Br J Clin Pharmacol |
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| Main Authors: | , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
John Wiley and Sons Inc.
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4876189/ https://ncbi.nlm.nih.gov/pubmed/26808419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12889 |
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