Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation

AIMS: Using the fluconazole–zidovudine (AZT) interaction as a model, to determine whether inhibition of UDP–glucuronosyltransferase (UGT) catalysed drug metabolism in vivo could be predicted quantitatively from in vitro kinetic data generated in the presence and absence bovine serum albumin (BSA). M...

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Bibliografiske detaljer
Main Authors: Uchaipichat, Verawan, Winner, Leanne K, Mackenzie, Peter I, Elliot, David J, Williams, J Andrew, Miners, John O
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2006
Fag:
Drug Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885031/
https://ncbi.nlm.nih.gov/pubmed/16542204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02588.x
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