Induction of zidovudine glucuronidation and amination pathways by rifampicin in HIV-infected patients

AIMS: The objective of the study was to determine the effect of multiple doses of rifampicin on the steady-state pharmacokinetics of zidovudine and its 5′-glucuronosyl (GZDV) and 3′-amino (AMT) metabolites. METHODS: Eight asymptomatic HIV-infected patients (seven male, one female) participated in th...

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Dettagli Bibliografici
Autori principali: Gallicano, Keith D, Sahai, Jan, Shukla, Vijay K, Seguin, Isabelle, Pakuts, Attila, Kwok, David, Foster, Brian C, Cameron, D William
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 1999
Soggetti:
Drug Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014298/
https://ncbi.nlm.nih.gov/pubmed/10417493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00987.x
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