Pharmacokinetics of ruboxistaurin are significantly altered by rifampicin-mediated CYP3A4 induction

AIMS: The aim of this study was to evaluate the effect of rifampicin co-administration on the pharmacokinetics of ruboxistaurin and its active metabolite, N-desmethyl ruboxistaurin and, in addition, to compare the changes in pharmacokinetics of ruboxistaurin and N-desmethyl ruboxistaurin with the ur...

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Bibliografiske detaljer
Main Authors: Yeo, Kwee Poo, Lowe, Stephen L, Lim, Ming Tung, Voelker, James R, Burkey, Jennifer L, Wise, Stephen D
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2006
Fag:
Drug Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884993/
https://ncbi.nlm.nih.gov/pubmed/16433874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02540.x
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