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Modulation of the Human Glucuronosyltransferase UGT1A Pathway by Splice Isoform Polypeptides Is Mediated through Protein-Protein Interactions

This study investigated the molecular mechanisms underlying the regulatory effect of the newly discovered 45-kDa enzymatically inactive UGT1A spliced polypeptides, named isoform i2, upon UGT1A-mediated glucuronidation. Initially, using an inducible system that mimics the relative abundance of isofor...

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Detalhes bibliográficos
Principais autores: Bellemare, Judith, Rouleau, Mélanie, Harvey, Mario, Guillemette, Chantal
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823500/
https://ncbi.nlm.nih.gov/pubmed/19996319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.083139
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