A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients

The risk of severe irinotecan-induced neutropenia has been shown to be related to the UGT1 variant UGT1A1*28, which increases exposure to the potent metabolite SN-38. Our goal was to identify a novel UGT1 marker(s) using 28 haplotype-tagged single nucleotide polymorphisms genotyped by mass spectrome...

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Vydáno v:Pharmacogenomics J
Hlavní autoři: Chen, Sylvia, Laverdiere, Isabelle, Tourancheau, Alan, Jonker, Derek, Couture, Félix, Cecchin, Erika, Villeneuve, Lyne, Harvey, Mario, Court, Michael H., Innocenti, Federico, Toffoli, Giuseppe, Lévesque, Eric, Guillemette, Chantal
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6174029/
https://ncbi.nlm.nih.gov/pubmed/25778466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2015.12
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