UGT1A1 Polymorphism for Irinotecan Dose Escalation in Patients with BRAF-Mutated Metastatic Colorectal Cancer Treated with First-Line Bevacizumab and FOLFIRI

BACKGROUND: Patients with metastatic colorectal cancer (mCRC) and BRAF V600E mutation have a poor prognosis, with a median progression-free survival (PFS) of only 5–7 months after initial therapy. The current standard first-line chemotherapy for these patients includes FOLFOX or FOLFIRI plus bevaciz...

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Bibliographic Details
Published in:J Oncol
Main Authors: Hsieh, Yi-Chien, Chang, Tsung-Kun, Su, Wei-Chih, Huang, Ching-Wen, Tsai, Hsiang-Lin, Chen, Yen-Cheng, Li, Ching-Chun, Chen, Po-Jung, Yin, Tzu-Chieh, Ma, Cheng-Jen, Wang, Jaw-Yuan
Format: Artigo
Language:Inglês
Published: Hindawi 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7972843/
https://ncbi.nlm.nih.gov/pubmed/33777142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/6686517
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