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Epithelial–mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib

Although cyclooxygenase-2 (COX-2) inhibitors, such as the late stage development drug apricoxib, exhibit antitumor activity, their mechanisms of action have not been fully defined. In this study, we characterized the mechanisms of action of apricoxib in HT29 colorectal carcinoma. Apricoxib was weakl...

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מידע ביבליוגרפי
Main Authors: Kirane, Amanda, Toombs, Jason E, Larsen, Jill E, Ostapoff, Katherine T, Meshaw, Kathryn R, Zaknoen, Sara, Brekken, Rolf A, Burrows, Francis J
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514897/
https://ncbi.nlm.nih.gov/pubmed/22678114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs195
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