Aneuploidy, oncogene amplification and epithelial to mesenchymal transition define spontaneous transformation of murine epithelial cells

Human epithelial cancers are defined by a recurrent distribution of specific chromosomal aneuploidies, a trait less typical for murine cancer models induced by an oncogenic stimulus. After prolonged culture, mouse epithelial cells spontaneously immortalize, transform and become tumorigenic. We asses...

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Detalhes bibliográficos
Main Authors: Padilla-Nash, Hesed M., McNeil, Nicole E., Yi, Ming, Nguyen, Quang-Tri, Hu, Yue, Wangsa, Danny, Mack, David L., Hummon, Amanda B., Case, Chanelle, Cardin, Eric, Stephens, Robert, Difilippantonio, Michael J., Ried, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Original Manuscript
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731808/
https://ncbi.nlm.nih.gov/pubmed/23619298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt138
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