Epithelial–mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib

Although cyclooxygenase-2 (COX-2) inhibitors, such as the late stage development drug apricoxib, exhibit antitumor activity, their mechanisms of action have not been fully defined. In this study, we characterized the mechanisms of action of apricoxib in HT29 colorectal carcinoma. Apricoxib was weakl...

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Detalhes bibliográficos
Main Authors: Kirane, Amanda, Toombs, Jason E, Larsen, Jill E, Ostapoff, Katherine T, Meshaw, Kathryn R, Zaknoen, Sara, Brekken, Rolf A, Burrows, Francis J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
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Original Manuscript
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514897/
https://ncbi.nlm.nih.gov/pubmed/22678114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs195
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