Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events

Lung cancer is a highly heterogeneous disease in terms of both underlying genetic lesions and response to therapeutic treatments. We performed deep whole-genome sequencing and transcriptome sequencing on 19 lung cancer cell lines and three lung tumor/normal pairs. Overall, our data show that cell li...

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Detalhes bibliográficos
Main Authors: Liu, Jinfeng, Lee, William, Jiang, Zhaoshi, Chen, Zhongqiang, Jhunjhunwala, Suchit, Haverty, Peter M., Gnad, Florian, Guan, Yinghui, Gilbert, Houston N., Stinson, Jeremy, Klijn, Christiaan, Guillory, Joseph, Bhatt, Deepali, Vartanian, Steffan, Walter, Kimberly, Chan, Jocelyn, Holcomb, Thomas, Dijkgraaf, Peter, Johnson, Stephanie, Koeman, Julie, Minna, John D., Gazdar, Adi F., Stern, Howard M., Hoeflich, Klaus P., Wu, Thomas D., Settleman, Jeff, de Sauvage, Frederic J., Gentleman, Robert C., Neve, Richard M., Stokoe, David, Modrusan, Zora, Seshagiri, Somasekar, Shames, David S., Zhang, Zemin
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514662/
https://ncbi.nlm.nih.gov/pubmed/23033341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.140988.112
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