Diverse modes of genomic alteration in hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) is a heterogeneous disease with high mortality rate. Recent genomic studies have identified TP53, AXIN1, and CTNNB1 as the most frequently mutated genes. Lower frequency mutations have been reported in ARID1A, ARID2 and JAK1. In addition, hepatitis B virus...

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Detalhes bibliográficos
Main Authors: Jhunjhunwala, Suchit, Jiang, Zhaoshi, Stawiski, Eric W, Gnad, Florian, Liu, Jinfeng, Mayba, Oleg, Du, Pan, Diao, Jingyu, Johnson, Stephanie, Wong, Kwong-Fai, Gao, Zhibo, Li, Yingrui, Wu, Thomas D, Kapadia, Sharookh B, Modrusan, Zora, French, Dorothy M, Luk, John M, Seshagiri, Somasekar, Zhang, Zemin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189592/
https://ncbi.nlm.nih.gov/pubmed/25159915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0436-9
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