Diverse modes of genomic alteration in hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) is a heterogeneous disease with high mortality rate. Recent genomic studies have identified TP53, AXIN1, and CTNNB1 as the most frequently mutated genes. Lower frequency mutations have been reported in ARID1A, ARID2 and JAK1. In addition, hepatitis B virus...

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Autori principali: Jhunjhunwala, Suchit, Jiang, Zhaoshi, Stawiski, Eric W, Gnad, Florian, Liu, Jinfeng, Mayba, Oleg, Du, Pan, Diao, Jingyu, Johnson, Stephanie, Wong, Kwong-Fai, Gao, Zhibo, Li, Yingrui, Wu, Thomas D, Kapadia, Sharookh B, Modrusan, Zora, French, Dorothy M, Luk, John M, Seshagiri, Somasekar, Zhang, Zemin
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189592/
https://ncbi.nlm.nih.gov/pubmed/25159915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0436-9
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