Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington’s disease

Oxidative damage and mitochondrial dysfunction are implicated in aging and age-related neurodegenerative diseases, including Huntington’s disease (HD). Many naturally occurring antioxidants have been tested to correct for deleterious effects of reactive oxygen species, but often they lack specificit...

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Hoofdauteurs: Xun, Zhiyin, Rivera-Sanchez, Sulay, Ayala-Penã, Sylvette, Lim, James, Budworth, Helen, Skoda, Erin M., Robbins, Paul D., Niedernhofer, Laura J., Wipf, Peter, McMurray, Cynthia T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513647/
https://ncbi.nlm.nih.gov/pubmed/23122961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.10.001
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