Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes

Oxidative damage to mitochondria (MT) is a major mechanism for aging and neurodegeneration. We have developed a novel synthetic antioxidant, XJB-5-131, which directly targets MT, the primary site and primary target of oxidative damage. XJB-5-131 prevents the onset of motor decline in an HdhQ(150/150...

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Bibliografiset tiedot
Julkaisussa:Hum Mol Genet
Päätekijät: Polyzos, Aris, Holt, Amy, Brown, Christopher, Cosme, Celica, Wipf, Peter, Gomez-Marin, Alex, Castro, Maríadel R., Ayala-Peña, Sylvette, McMurray, Cynthia T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2016
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986333/
https://ncbi.nlm.nih.gov/pubmed/26908614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw051
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