Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the HdhQ150/Q150 Mouse Model of Huntington’s Disease

A variety of mouse models have been developed that express mutant huntingtin (mHTT) leading to aggregates and inclusions that model the molecular pathology observed in Huntington’s disease. Here we show that although homozygous HdhQ150 knock-in mice developed motor impairments (rotarod, locomotor ac...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Rattray, Ivan, Smith, Edward J., Crum, William R., Walker, Thomas A., Gale, Richard, Bates, Gillian P., Modo, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242535/
https://ncbi.nlm.nih.gov/pubmed/28099507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168556
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