Utility of PTEN Protein Dosage in Predicting for Underlying Germline PTEN Mutations among Patients Presenting with Thyroid Cancer and Cowden-Like Phenotypes

CONTEXT: Thyroid cancer is a major component of Cowden syndrome (CS). CS patients with an underlying PTEN mutation (PTEN(mut+)) have a 70-fold increased risk of developing epithelial thyroid cancer. In contrast, less than 1% of sporadic epithelial thyroid cancer patients carry a germline PTEN mutati...

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Detalhes bibliográficos
Main Authors: Ngeow, Joanne, He, Xin, Mester, Jessica L., Lei, Junying, Romigh, Todd, Orloff, Mohammed S., Milas, Mira, Eng, Charis
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
JCEM Online: Advances in Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513537/
https://ncbi.nlm.nih.gov/pubmed/23066114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-2944
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