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Characterization of cryptic splicing in germline PTEN intronic variants in Cowden syndrome

Germline mutations in the tumor‐suppressor gene PTEN predispose to subsets of Cowden syndrome (CS), Bannayan–Riley–Ruvalcaba syndrome, and autism. Evidence‐based classification of PTEN variants as either deleterious or benign is urgently needed for accurate molecular diagnosis and gene‐informed gene...

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Bibliografski detalji
Izdano u:Hum Mutat
Glavni autori: Chen, Hannah Jinlian, Romigh, Todd, Sesock, Kaitlin, Eng, Charis
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599331/
https://ncbi.nlm.nih.gov/pubmed/28677221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.23288
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