PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome

CONTEXT: Germline mutations in PTEN are associated with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) hamartoma tumor syndrome including Cowden syndrome (CS) and Cowden-like syndrome (CSL) that predisposes to high risks of benign and malignant tumors of thyroid and breast. OBJECTIVE...

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Detalhes bibliográficos
Main Authors: He, Xin, Saji, Motoyasu, Radhakrishnan, Deepa, Romigh, Todd, Ngeow, Joanne, Yu, Qi, Wang, Yu, Ringel, Matthew D., Eng, Charis
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
JCEM Online: Advances in Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485596/
https://ncbi.nlm.nih.gov/pubmed/22962422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-1991
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