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Synthesis of 5-oxyquinoline derivatives for reversal of multidrug resistance
The inhibition of ABC (ATP binding cassette) transporters is considered a powerful tool to reverse multidrug resistance. Zosuquidar featuring a difluorocyclopropyl-annulated dibenzosuberyl moiety has been found to be an inhibitor of the P-glycoprotein, one of the best-studied multidrug efflux pumps....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Beilstein-Institut
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3511002/ https://ncbi.nlm.nih.gov/pubmed/23209502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.8.193 |
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