Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study

Overexpression of the efflux pump P-glycoprotein (P-gp) is one of the important mechanisms of multidrug resistance (MDR) in many tumor cells. In this study, 26 novel 5-oxo-hexahydroquinoline derivatives containing different nitrophenyl moieties at C(4) and various carboxamide substituents at C(3) we...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Drug Des Devel Ther
Hauptverfasser: Shahraki, Omolbanin, Edraki, Najmeh, Khoshneviszadeh, Mehdi, Zargari, Farshid, Ranjbar, Sara, Saso, Luciano, Firuzi, Omidreza, Miri, Ramin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2017
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5317256/
https://ncbi.nlm.nih.gov/pubmed/28243063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S119995
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