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Identification of Extracellular Domain Residues Required for Epithelial Na(+) Channel Activation by Acidic pH

A growing body of evidence suggests that the extracellular domain of the epithelial Na(+) channel (ENaC) functions as a sensor that fine tunes channel activity in response to changes in the extracellular environment. We previously found that acidic pH increases the activity of human ENaC, which resu...

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Autori principali: Collier, Daniel M., Peterson, Zerubbabel J., Blokhin, Ilya O., Benson, Christopher J., Snyder, Peter M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510795/
https://ncbi.nlm.nih.gov/pubmed/23060445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.417519
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