TBK1 Kinase Addiction in Lung Cancer Cells Is Mediated via Autophagy of Tax1bp1/Ndp52 and Non-Canonical NF-κB Signalling

K-Ras dependent non-small cell lung cancer (NSCLC) cells are ‘addicted’ to basal autophagy that reprograms cellular metabolism in a lysosomal-sensitive manner. Here we demonstrate that the xenophagy-associated kinase TBK1 drives basal autophagy, consistent with its known requirement in K-Ras-depende...

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Autores principales: Newman, Alice C., Scholefield, Caroline L., Kemp, Alain J., Newman, Michelle, McIver, Edward G., Kamal, Ahmad, Wilkinson, Simon
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510188/
https://ncbi.nlm.nih.gov/pubmed/23209807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050672
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