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TAX1BP1 and A20 Inhibit Antiviral Signaling by Targeting TBK1-IKKi Kinases
Induction of type I interferons by the transcription factor IRF3 is essential in the initiation of antiviral innate immunity. Activation of IRF3 requires C-terminal phosphorylation by the upstream kinases TBK1-IKKi, where IRF3 phosphorylation promotes dimerization, and subsequent nuclear translocati...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2865285/ https://ncbi.nlm.nih.gov/pubmed/20304918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.109819 |
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