Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides

A second-generation series of substituted methylenecyclopropane nucleosides (MCPNs) has been synthesized and evaluated for antiviral activity against a panel of human herpesviruses, and for cytotoxicity. Although alkylated 2,6-diaminopurine analogs showed little antiviral activity, the compounds con...

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Hauptverfasser: Williams, John D., Khan, Atiyya R., Harden, Emma A., Hartline, Caroll B., Jefferson, Geraldine M., Keith, Kathy A., Prichard, Mark N., Zemlicka, Jiri, Peet, Norton P., Bowlin, Terry L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509806/
https://ncbi.nlm.nih.gov/pubmed/22607883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.04.049
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