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Membrane permeable local anesthetics modulate Na(V)1.5 mechanosensitivity
Voltage-gated sodium selective ion channel Na(V)1.5 is expressed in the heart and the gastrointestinal tract, which are mechanically active organs. Na(V)1.5 is mechanosensitive at stimuli that gate other mechanosensitive ion channels. Local anesthetic and antiarrhythmic drugs act upon Na(V)1.5 to mo...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Landes Bioscience
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3508909/ https://ncbi.nlm.nih.gov/pubmed/22874086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.21202 |
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