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Hsp104 Drives ‘Protein-Only’ Positive Selection of Sup35 Prion Strains Encoding Strong [PSI(+)]
Structurally distinct, self-templating prion ‘strains’ can encode distinct phenotypes and amplify at different rates depending upon the environment. Indeed, prion strain ensembles can evolve in response to environmental challenges, which makes them highly challenging drug targets. It is not understo...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3508465/ https://ncbi.nlm.nih.gov/pubmed/23177195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.09.013 |
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