Design of a New [PSI(+)]-No-More Mutation in SUP35 With Strong Inhibitory Effect on the [PSI(+)] Prion Propagation

A number of [PSI(+)]-no-more (PNM) mutations, eliminating [PSI(+)] prion, were previously described in SUP35. In this study, we designed and analyzed a new PNM mutation based on the parallel in-register β-structure of Sup35 prion fibrils suggested by the known experimental data. In such an arrangeme...

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Bibliografske podrobnosti
izdano v:Front Mol Neurosci
Main Authors: Danilov, Lavrentii G., Matveenko, Andrew G., Ryzhkova, Varvara E., Belousov, Mikhail V., Poleshchuk, Olga I., Likholetova, Daria V., Sokolov, Petr A., Kasyanenko, Nina A., Kajava, Andrey V., Zhouravleva, Galina A., Bondarev, Stanislav A.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877606/
https://ncbi.nlm.nih.gov/pubmed/31803017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00274
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