Design of a New [PSI(+)]-No-More Mutation in SUP35 With Strong Inhibitory Effect on the [PSI(+)] Prion Propagation

A number of [PSI(+)]-no-more (PNM) mutations, eliminating [PSI(+)] prion, were previously described in SUP35. In this study, we designed and analyzed a new PNM mutation based on the parallel in-register β-structure of Sup35 prion fibrils suggested by the known experimental data. In such an arrangeme...

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Bibliographic Details
Published in:Front Mol Neurosci
Main Authors: Danilov, Lavrentii G., Matveenko, Andrew G., Ryzhkova, Varvara E., Belousov, Mikhail V., Poleshchuk, Olga I., Likholetova, Daria V., Sokolov, Petr A., Kasyanenko, Nina A., Kajava, Andrey V., Zhouravleva, Galina A., Bondarev, Stanislav A.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877606/
https://ncbi.nlm.nih.gov/pubmed/31803017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00274
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