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Design of a New [PSI(+)]-No-More Mutation in SUP35 With Strong Inhibitory Effect on the [PSI(+)] Prion Propagation
A number of [PSI(+)]-no-more (PNM) mutations, eliminating [PSI(+)] prion, were previously described in SUP35. In this study, we designed and analyzed a new PNM mutation based on the parallel in-register β-structure of Sup35 prion fibrils suggested by the known experimental data. In such an arrangeme...
Zapisane w:
| Wydane w: | Front Mol Neurosci |
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| Główni autorzy: | , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Frontiers Media S.A.
2019
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6877606/ https://ncbi.nlm.nih.gov/pubmed/31803017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00274 |
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