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DEFECTS IN SPLICEOSOMAL MACHINERY: A NEW PATHWAY OF LEUKEMOGENESIS

Proper splicing of pre-mRNA is required for protein synthesis and therefore is a fundamental cellular function. The discovery of a variety of somatic spliceosomal mutations in hematologic malignancies, including myeloid neoplasms and chronic lymphocytic leukemia has pointed to a new leukemogenic pat...

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Bibliographic Details
Main Authors: Maciejewski, Jaroslaw P., Padgett, Richard A.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507475/
https://ncbi.nlm.nih.gov/pubmed/22594801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2012.09158.x
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