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DEFECTS IN SPLICEOSOMAL MACHINERY: A NEW PATHWAY OF LEUKEMOGENESIS
Proper splicing of pre-mRNA is required for protein synthesis and therefore is a fundamental cellular function. The discovery of a variety of somatic spliceosomal mutations in hematologic malignancies, including myeloid neoplasms and chronic lymphocytic leukemia has pointed to a new leukemogenic pat...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3507475/ https://ncbi.nlm.nih.gov/pubmed/22594801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2012.09158.x |
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