Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis

Myelodysplastic syndromes (MDSs) are chronic and often progressive myeloid neoplasms associated with remarkable heterogeneity in the histomorphology and clinical course. Various somatic mutations are involved in the pathogenesis of MDS. Recently, mutations in a gene encoding a spliceosomal protein,...

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Autores principales: Makishima, Hideki, Visconte, Valeria, Sakaguchi, Hirotoshi, Jankowska, Anna M., Abu Kar, Sarah, Jerez, Andres, Przychodzen, Bartlomiej, Bupathi, Manoj, Guinta, Kathryn, Afable, Manuel G., Sekeres, Mikkael A., Padgett, Richard A., Tiu, Ramon V., Maciejewski, Jaroslaw P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2012
Materias:
Plenary Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321850/
https://ncbi.nlm.nih.gov/pubmed/22323480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-399774
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