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Macrophage activation by factors released from acetaminophen-injured hepatocytes. Potential role of HMGB1

Toxic doses of acetaminophen (AA) cause hepatocellular necrosis. Evidence suggests that activated macrophages contribute to the pathogenic process; however, the factors that activate these cells are unknown. In these studies, we assessed the role of mediators released from AA-injured hepatocytes in...

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Hlavní autoři: Dragomir, Ana-Cristina, Laskin, Jeffrey D., Laskin, Debra L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507385/
https://ncbi.nlm.nih.gov/pubmed/21513726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2011.04.003
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