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RELATCH: relative optimality in metabolic networks explains robust metabolic and regulatory responses to perturbations

Predicting cellular responses to perturbations is an important task in systems biology. We report a new approach, RELATCH, which uses flux and gene expression data from a reference state to predict metabolic responses in a genetically or environmentally perturbed state. Using the concept of relative...

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Hlavní autoři: Kim, Joonhoon, Reed, Jennifer L
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506949/
https://ncbi.nlm.nih.gov/pubmed/23013597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2012-13-9-r78
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