Fumaroylamino-4,5-epoxymorphinans and Related Opioids with Irreversible μ Opioid Receptor Antagonist Effects

[Image: see text] We have previously shown that cinnamoyl derivatives of 14β-amino-17-cyclopropylmethyl-7,8-dihydronormorphinone and 7α-aminomethyl-6,14-endoethanonororipavine have pronounced pseudoirreversible μ opioid receptor (MOR) antagonism. The present communication describes the synthesis and...

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Autores principales: Moynihan, Humphrey A., Derrick, Ian., Broadbear, Jillian H., Greedy, Benjamin M., Aceto, Mario D., Harris, Louis S., Purington, Lauren C. S., Thomas, Mark P., Woods, James H., Traynor, John R., Husbands, Stephen M., Lewis, John W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2012
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506128/
https://ncbi.nlm.nih.gov/pubmed/23043264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301096s
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