14β-Arylpropiolylamino-17-cyclopropylmethyl-7,8-dihydronormorphinones and related opioids. Further examples of pseudo-irreversible mu opioid receptor antagonists

14β-4’-Chlorocinnamoylaminodihydronormorphinone (2a), and analogues, are selective pseudoirreversible antagonists of the mu opioid receptor (MOR). The preparation of analogues with ethynic bonds, replacing the ethenic bond of 2a, is described. The new ligands, in mouse antinociceptive assays, had ps...

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Bibliografische gegevens
Hoofdauteurs: Nieland, Nick P.R., Rennison, David, Broadbear, Jillian H., Purington, Lauren, Woods, James H., Traynor, John R., Lewis, John W., Husbands, Stephen M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788771/
https://ncbi.nlm.nih.gov/pubmed/19842669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901074a
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