Immortalization of Human Mammary Epithelial Cells Is Associated with Inactivation of the p14(ARF)-p53 Pathway

Inactivation of the ARF-p53 tumor suppressor pathway leads to immortalization of murine fibroblasts. The role of this pathway in immortalization of human epithelial cells is not clear. We analyzed the functionality of the p14(ARF)-p53 pathway in human mammary epithelial cells (MEC) immortalized by h...

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Bibliographische Detailangaben
Hauptverfasser: Shamanin, Vladimir A., Androphy, Elliot J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC350550/
https://ncbi.nlm.nih.gov/pubmed/14966292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.5.2144-2152.2004
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