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Botulinum Neurotoxin Serotype C Associates with Dual Ganglioside Receptors to Facilitate Cell Entry

Botulinum neurotoxins (BoNTs) cleave SNARE proteins in motor neurons that inhibits synaptic vesicle (SV) exocytosis, resulting in flaccid paralysis. There are seven BoNT serotypes (A–G). In current models, BoNTs initially bind gangliosides on resting neurons and upon SV exocytosis associate with the...

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Detalles Bibliográficos
Main Authors: Karalewitz, Andrew P.-A., Fu, Zhuji, Baldwin, Michael R., Kim, Jung-Ja P., Barbieri, Joseph T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504792/
https://ncbi.nlm.nih.gov/pubmed/23027864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404244
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