Botulinum Neurotoxin Serotype C Associates with Dual Ganglioside Receptors to Facilitate Cell Entry

Botulinum neurotoxins (BoNTs) cleave SNARE proteins in motor neurons that inhibits synaptic vesicle (SV) exocytosis, resulting in flaccid paralysis. There are seven BoNT serotypes (A–G). In current models, BoNTs initially bind gangliosides on resting neurons and upon SV exocytosis associate with the...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Karalewitz, Andrew P.-A., Fu, Zhuji, Baldwin, Michael R., Kim, Jung-Ja P., Barbieri, Joseph T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2012
Gaiak:
Microbiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504792/
https://ncbi.nlm.nih.gov/pubmed/23027864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404244
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