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Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA

The botulinum neurotoxins (BoNTs) are the most potent protein toxins for humans. There are seven serotypes of BoNTs (A-G) based on a lack of cross anti-sera neutralization. BoNTs utilize gangliosides as components of the host receptors for binding and entry into neurons. Members of BoNT/C and BoNT/D...

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Detalhes bibliográficos
Main Authors: Karalewitz, Andrew P-A., Kroken, Abby R., Fu, Zhuji, Baldwin, Michael R., Kim, Jung-Ja P., Barbieri, Joseph T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939319/
https://ncbi.nlm.nih.gov/pubmed/20731382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100865f
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