Inhibition of Mycobacterium tuberculosis methionine aminopeptidases by bengamide derivatives

Methionine aminopeptidase (MetAP) carries out an essential function of protein N-terminal processing in many bacteria and is a promising target to develop novel antitubercular agents. Natural bengamides potently inhibit proliferation of mammalian cells by targeting MetAP enzymes, and the X-ray struc...

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Bibliografiske detaljer
Main Authors: Lu, Jing-Ping, Yuan, Xiu-Hua, Yuan, Hai, Wang, Wen-Long, Wan, Baojie, Franzblau, Scott G., Ye, Qi-Zhuang
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504309/
https://ncbi.nlm.nih.gov/pubmed/21465667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100003
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