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Impaired Autophagy in Neurons after Disinhibition of Mammalian Target of Rapamycin and Its Contribution to Epileptogenesis

Certain mutations within the mammalian target of rapamycin (mTOR) pathway, most notably those affecting the tuberous sclerosis complex (TSC), lead to aberrant activation of mTOR and result in a high incidence of epilepsy in humans and animal models. Although hyperactivation of mTOR has been strongly...

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Autors principals: McMahon, John, Huang, Xiaoxing, Yang, Jun, Komatsu, Masaaki, Yue, Zhenyu, Qian, Jiang, Zhu, Xinjun, Huang, Yunfei
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501684/
https://ncbi.nlm.nih.gov/pubmed/23136410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2392-12.2012
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