The Rapamycin-Binding Domain Governs Substrate Selectivity by the Mammalian Target of Rapamycin

The mammalian target of rapamycin (mTOR) is a Ser/Thr (S/T) protein kinase, which controls mRNA translation initiation by modulating phosphorylation of the translational regulators PHAS-I and p70(S6K). Here we show that in vitro mTOR is able to phosphorylate these two regulators at comparable rates....

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Detalhes bibliográficos
Main Authors: McMahon, Lloyd P., Choi, Kin M., Lin, Tai-An, Abraham, Robert T., Lawrence, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135667/
https://ncbi.nlm.nih.gov/pubmed/12370290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.21.7428-7438.2002
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