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The Rapamycin-Binding Domain Governs Substrate Selectivity by the Mammalian Target of Rapamycin
The mammalian target of rapamycin (mTOR) is a Ser/Thr (S/T) protein kinase, which controls mRNA translation initiation by modulating phosphorylation of the translational regulators PHAS-I and p70(S6K). Here we show that in vitro mTOR is able to phosphorylate these two regulators at comparable rates....
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC135667/ https://ncbi.nlm.nih.gov/pubmed/12370290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.21.7428-7438.2002 |
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