The Rapamycin-Binding Domain Governs Substrate Selectivity by the Mammalian Target of Rapamycin

The mammalian target of rapamycin (mTOR) is a Ser/Thr (S/T) protein kinase, which controls mRNA translation initiation by modulating phosphorylation of the translational regulators PHAS-I and p70(S6K). Here we show that in vitro mTOR is able to phosphorylate these two regulators at comparable rates....

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Autores principales:	McMahon, Lloyd P., Choi, Kin M., Lin, Tai-An, Abraham, Robert T., Lawrence, John C.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 2002
Materias:	Cell Growth and Development
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135667/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12370290/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.21.7428-7438.2002
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