Impaired Autophagy in Neurons after Disinhibition of Mammalian Target of Rapamycin and Its Contribution to Epileptogenesis

Certain mutations within the mammalian target of rapamycin (mTOR) pathway, most notably those affecting the tuberous sclerosis complex (TSC), lead to aberrant activation of mTOR and result in a high incidence of epilepsy in humans and animal models. Although hyperactivation of mTOR has been strongly...

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Detalhes bibliográficos
Main Authors: McMahon, John, Huang, Xiaoxing, Yang, Jun, Komatsu, Masaaki, Yue, Zhenyu, Qian, Jiang, Zhu, Xinjun, Huang, Yunfei
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501684/
https://ncbi.nlm.nih.gov/pubmed/23136410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2392-12.2012
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