Vα14iNKT cell Deficiency Prevents Acetaminophen-Induced Acute Liver Failure by Enhancing Hepatic Glutathione and Altering APAP Metabolism

Acetaminophen (APAP) overdose is widely regarded as a major cause of acute liver failure in the United States. Intentional or accidental overdose of APAP in man or rodent elicits direct hepatocellular injury that is accompanied by hepatic depletion of the antioxidant, glutathione (GSH). In recent ye...

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Main Authors: Downs, Isaac, Aw, Tak Yee, Liu, Jianfeng, Adegboyega, Patrick, Ajuebor, Maureen N.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501592/
https://ncbi.nlm.nih.gov/pubmed/23079619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.10.029
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