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Vα14iNKT cell Deficiency Prevents Acetaminophen-Induced Acute Liver Failure by Enhancing Hepatic Glutathione and Altering APAP Metabolism
Acetaminophen (APAP) overdose is widely regarded as a major cause of acute liver failure in the United States. Intentional or accidental overdose of APAP in man or rodent elicits direct hepatocellular injury that is accompanied by hepatic depletion of the antioxidant, glutathione (GSH). In recent ye...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3501592/ https://ncbi.nlm.nih.gov/pubmed/23079619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.10.029 |
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