The Ubiquitin Ligase TRAF6 Negatively Regulates the JAK-STAT Signaling Pathway by Binding to STAT3 and Mediating Its Ubiquitination

STAT3 is a key transcription factor that mediates various cellular and organismal processes, such as cell growth, apoptosis, immune response and cancer. However, the molecular mechanisms of STAT3 regulation remain poorly understood. Here, we identified TRAF6 as a new STAT3 interactor. TRAF6 augmente...

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מידע ביבליוגרפי
Main Authors: Wei, Juncheng, Yuan, Yanzhi, Jin, Chaozhi, Chen, Hui, Leng, Ling, He, Fuchu, Wang, Jian
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501508/
https://ncbi.nlm.nih.gov/pubmed/23185365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049567
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