The Scaffold Protein TANK/I-TRAF Inhibits NF-κB Activation by Recruiting Polo-like Kinase 1

TANK/I-TRAF is a TRAF-binding protein that negatively regulates NF-κB activation. The underlying mechanism of this activity remains unclear. Here we show that TANK directly interacts with PLK1, a conserved cell cycle–regulated kinase. PLK1 inhibits NF-κB transcriptional activation induced by TNF-α,...

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Main Authors: Zhang, Wanqiao, Wang, Jian, Zhang, Ying, Yuan, Yanzhi, Guan, Wei, Jin, Chaozhi, Chen, Hui, Wang, Xiaohui, Yang, Xiaoming, He, Fuchu
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903677/
https://ncbi.nlm.nih.gov/pubmed/20484576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-08-0715
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